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KMID : 0043319930160040336
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Archives of Pharmacal Research
1993 Volume.16 No. 4 p.336 ~ p.338
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Effect of Kp, an Antitumor Protein-Polysaccharide from Mycelial Culture of Phellinus Linteus on the Humoral lammune Response of Tumor-Bearing ICR Mice to Sheep Red Blood Cells
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Chung Kyeong-Soo
Kim Shin-Sook
Kim Hee-Soo
Kim Kye-Yang
Han Man-Woo
Kim Kil-Hyun
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Abstract
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The immunomodulating activity of Kp, an antitumor protein-polysacchanide preparation from the shake-cultured mycelia of Phellinus linteus, was investigated in ICR mice subcutaneously implanted wit cells of sarcoma 180. The mice were intraperitoneally administered with Kp at a does of 100 mg/kg once daily for five consecutive days starting from 24 hrs after the tumor implantation. Ten days after the last injection, the mice were immunized with or sheep red blood cells (SRBC) and five days later, the antibody-forming immune response were assessed by direct hemolytic plaque assay. To an immunization does of SRBC, the Kp-treated mice elicied a successful humoral immune response despite the turmor-burden and produced plaque-forming cells (PFC)/spleen, while the corresponding tumor-bearing control mice showed virtually no reponse PFC/spleen) (the stimulation index=129.5). However, to an immunization dose of SRBC, both of the control mice and Kp-treated mice showed almost the same level of strong humoral immune response. From these data it is clear that Kp effectively restores the humoral immune response of the turmor-bearing ICR mice.
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KEYWORD
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Phellinus linteus, Kp, Antitumor, Protein-polysaccharide, Hemolytic plaque assay, Plaque-forming cells (PFC), Humoral immune response, lmmunorestoring, Immunomdulator
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